Intravenous iron-dextran: therapeutic and experimental possibilities. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. Do not administer Venofer to patients with iron overload. Introduction Uses Dosage Warnings Interactions Stability Introduction Hematinic agent; a polynuclear iron (III)-hydroxide sucrose complex. Applies only to oral form of both agents. This drug is available at a middle level co-pay. Use Caution/Monitor. Total dose iron infusion: safety and efficacy in predialysis patients. There are three fields in the parenteral iron replacement for iron deficiency anemia calculator: Weight can be input in either lbs or kilograms and the required transformations are performed by the calculator. Accessed: 4/12/2011. Applies only to oral form of both agents. Minor/Significance Unknown. Use Caution/Monitor. Indications: Feraheme is indicated for the treatment of iron deficiency anemia (IDA) in adult patients: who have intolerance to oral iron or have had unsatisfactory response to oral iron or who have chronic kidney disease (CKD). Applies only to oral form of both agents. pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. 2) Koch TA, Myers J, Goodnough LT. (2015) Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Always ask your health care professional for complete information about this product and your specific health needs. Each mL contains 20 mg of elemental iron. Modify Therapy/Monitor Closely. Coadministration of ciprofloxacin with multivalent cation-containing products may reduce the bioavailability of ciprofloxacin by 90%. Deferasirox chelates iron. Applies only to oral form of both agents. Applies only to oral form of both agents. iron sucrose increases levels of calcium chloride by enhancing GI absorption. Interaction only with oral iron administration. Applies only to oral form of both agents. 200-800 mg/kg (2-8 mL/kg) every 3-4 weeks. When to Use Weight lbs Target hemoglobin g/dL Actual hemoglobin g/dL Iron stores Use 500 mg for adults and children 35 kg; use 15 mg/kg if <35 kg mg Result: Please fill out required fields. IDA symptoms vary, may not be specific and include tiredness, weakness, shortness of breath. Administer Venofer 200 mg undiluted as a slow intravenous injection over 2 to 5 minutes or as an infusion of 200 mg in a maximum of 100 mL of 0.9% NaCl over a period of 15 minutes. ADMINISTER THE TEST DOSE AT A GRADUAL RATE OVER AT LEAST 30 SECONDS. Iron sucrose: 20 mg/mL. The usual adult total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. Serious - Use Alternative (1)iron sucrose decreases levels of demeclocycline by inhibition of GI absorption. ]Venofer treatment may be repeated if iron deficiency reoccurs. Applies only to oral form of both agents. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Symptoms associated with Venofer total dosage or infusing too rapidly included hypotension, dyspnea, headache, vomiting, nausea, dizziness, joint aches, paresthesia, abdominal and muscle pain, edema and cardiovascular collapse. Minor/Significance Unknown.iron sucrose increases levels of calcium acetate by enhancing GI absorption. In less advanced cases of iron deficiency, increases in dietary intake of iron may be sufficient. provider for the most current information. 1998 Feb;25(1):65-8. Serious - Use Alternative (1)iron sucrose decreases levels of fleroxacin by inhibition of GI absorption. IDA symptoms are often nonspecific and include tiredness, weakness, shortness of breath. INFED- iron dextran injection [Package insert], Hemoglobin iron deficit (mg) = weight (kg) x (14 - Hgb) x (2.145) Note: Hbg (current hemoglobin level) units: (g/dL) Alternatively: Volume of product required (mL) = [weight (kg) x (14 - Hgb) x (2.145)] / C Where C= concentration of elemental iron (mg/ml) in the product being used: Iron dextran: 50 mg/mL. Venofer treatment may be repeated if necessary. Serious - Use Alternative (1)iron sucrose decreases levels of eltrombopag by inhibition of GI absorption. Maintain a well-balanced diet, and follow any dietary guidelines as directed by your doctor. 1988 May;111(5):566-70. Calculosaurus | Medical calculators for obstetrics and gynaecology Use the menu to browse through our clinical calculators. Total cumulative Venofer dose = number of 100mg ampoules for Hb increase. Applies only to oral form of both agents. trientine, iron sucrose. Otherwise, call a poison control center right away. Adverse pregnancy outcomes associated with IDA include increased risk for preterm delivery and low birth weight. It is usually given slowly over 2 to 5 minutes or as directed by your doctor. iron sucrose increases levels of calcium citrate by enhancing GI absorption. Monitor Closely (1)iron sucrose decreases levels of methyldopa by inhibition of GI absorption. Applies only to oral form of both agents. Parenteral iron dextran therapy. Med J Aust. 0.5 mg/kg/min (0.005 mL/kg/min) Maximum infusion rate (if tolerated) Increase to 8 mg/kg/min (0.08 mL/kg/min) Monitor the patient's vital signs throughout the infusion. 2015: 763576. Fatal reactions have followed the test dose of iron dextran injection. iron sucrose increases levels of calcium carbonate by enhancing GI absorption. Minor (2)calcium acetate decreases levels of iron sucrose by inhibition of GI absorption. 1996 Aug;11(4):139-46. In a randomized, open-label, dose-ranging trial for iron maintenance treatment with Venofer in pediatric patients with CKD on stable erythropoietin therapy [see Clinical Studies ( 14.7)], at least one adverse reaction was experienced by 57% (27/47) of the patients receiving Venofer 0.5 mg/kg, 53% (25/47) of the patients receiving Venofer 1 mg . 2010niferex-hytinic-polysaccharide-iron-342160Drugs, You are being redirected to Applies only to oral form of both agents. Med J Aust; 193(9):525-32. Applies only to oral form of both agents. In most cases, adult patients require a cumulative dose of elemental iron of at least 1 g. Most commonly, iron replenishment therapy is done intravenously: As total dose (iron-dextran or iron carboxymaltose); Iron deficiency is common during childhood growth, prolonged periods of sickness, in convalescence or during pregnancy. Patients diagnosed with iron deficiency are prescribed iron supplementation, either to replete body stores or to correct anemia. Minor (2)calcium chloride decreases levels of iron sucrose by inhibition of GI absorption. Iron deficiency anemia is the type of anemia caused by iron depletion. Applies only to oral form of both agents. Intravenous (IV) iron products (use in adults) Dosing information in this table is for adults and includes some dosing recommendations not listed in the approved product information. The elemental iron product used is Iron sucrose 20 mg/mL. Venofer has not been studied in patients younger than 2 years old. J Med. Most Corrected Calcium. however iron sucrose requires multiple small intermittent doses over days to weeks. Administer Venofer early during the dialysis session (generally within the first hour). Consult your pharmacist or local waste disposal company. Maximum infusion rate: 100 mg / hour (Slow infusion rate of iron sucrose is recommended to minimize adverse reactions, especially hypotension) Frequency of infusion: Dose may be repeated up to 3 times weekly to provide total iron dose. IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. Am J HealthSyst Pharm 2006;63:731735. Sodium ferric gluconate complex injection [ Ferrlecit ] [package insert] - Elemental iron: 12.5 mg/mL (5 mL). This product may contain inactive ingredients, which can cause allergic reactions or other problems. Diluted with 0.9% Sodium Chloride Injection at concentrations of 1 to 2 mg/mL, 2 doses of 300 mg/250 mL over 1.5 hrsplus1 dose of 400 mg/250 mL over 2.5 hrs. 300-500 mg Iron Sucrose in NS 250 mL administered over three (3) hours; may repeat as needed in 3-7 days to reach 1 gm. Each mL contains 20 mg of elemental . Applies to didanosine chewable tablets and powder for oral solution; administer 2 hr before or several hours after didanosine oral solution or chewable tablet administration. Avoid or Use Alternate Drug. We have found the lower dose to be better tolerated in the second half of gestation. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. The Ganzoni equation is: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores In most cases, adult patients require a cumulative dose of elemental iron of at least 1 g. Most commonly, iron replenishment therapy is done intravenously: As total dose (iron-dextran or iron - carboxymaltose); Intermediate calculations: -Blood volume (dL) = [65 (mL/kg) x body weight (kg)] / 100 (mL/dL) -Hgb deficit (g/dL) = 14.0 - patient hemoglobin conc. Schweiz Med Wochenschr. Use Caution/Monitor. Applies only to oral form of both agents. By clicking send, you acknowledge that you have permission to email the recipient with this information. Venofer treatment may be repeated if necessary. Applies only to oral form of both agents. Where: Medicine concentration Amount of active substance per a given volume of your drug. Medically reviewed by Drugs.com. ONE DOSE. Monitor patients for signs and symptoms of hypersensitivity during and after Venofer administration for at least 30 minutes and until clinically stable following completion of the infusion. Avoid or Use Alternate Drug. 1974 Jun;31(6):592-5. Volume of iron sucrose needed = 60 x (14 - 8) x (2.145) 20 = 38.6 mL . Copyright 1993-2021 No data are available regarding overdosage of Venofer in humans. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: vitamin products, other iron-containing products. Applies only to oral form of both agents. Hypotension following administration of Venofer may be related to rate of administration and/or total dose delivered. 1990 Feb;24(2):162-6. iron sucrose increases levels of calcium acetate by enhancing GI absorption. Separate dosing of tetracyclines from these products. Deferiprone may bind polyvalent cations (eg, iron, aluminum, and zinc), separate administration by at least 4 hr between deferiprone and other medications (eg, antacids), or supplements containing these polyvalent cations. Applies to didanosine chewable tablets and powder for oral solution; administer 2 hr before or several hours after didanosine oral solution or chewable tablet administration. Schweiz Med Wochenschr; 100(7):301-3. The factor 2.4 comes about from the calculation that the total iron content of hemoglobin is 0.34%, the blood volume accounts for 7% . Applies only to oral form of both agents. Allow at least 30 minutes between administration of Feraheme and administration of other medications that could potentially cause serious hypersensitivity reactions and/or hypotension, such as chemotherapeutic agents or monoclonal antibodies. I. Applies only to oral form of both agents. Manufacturer advises for slow intravenous injection ( Venofer ), give undiluted at a rate of 1 mL/minute; do not exceed 10 mL (200 mg iron) per injection. iron sucrose decreases levels of eltrombopag by inhibition of GI absorption. Test Dose: Not required. Avoid or Use Alternate Drug. USES: This medicine is used to treat "iron-poor" blood (anemia) in people with long-term kidney disease. calcium carbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Monitor Closely (1)didanosine will decrease the level or effect of iron sucrose by increasing gastric pH. In post-marketing safety studies of Venofer in 1,051 patients with HDD-CKD, adverse reactions reported by >1% were cardiac failure congestive, sepsis and dysgeusia. Applies only to oral form of both agents. Minor/Significance Unknown. Adult Patients: The most common adverse reactions (2%) include diarrhea, nausea, vomiting, headache, dizziness, hypotension, pruritus, pain in extremity, arthralgia, back pain, muscle cramp, injection site reactions, chest pain and peripheral edema. You can further save the PDF or print it. Either decreases levels of the other by inhibition of GI absorption. Your doctor will do laboratory tests to monitor your response. 2. Use Caution/Monitor.Minor (2)calcium carbonate decreases levels of iron sucrose by inhibition of GI absorption. The dosage of Venofer is expressed in mg of elemental iron. informational and educational purposes only. 4) Gozzard D. (2011) When is high-dose intravenous iron repletion needed? Applies only to oral form of both agents. If no signs or symptoms of anaphylactic-type reactions follow the test dose, administer the full therapeutic INFeD dose. Use Caution/Monitor. You will have to pay for your IV iron. The incidence of adverse events with the 400- and 500-mg doses administered as a 2-hour . Venofer must only be administered intravenously either by slow injection or by infusion. 2.1 . Avoid or Use Alternate Drug. VENOFER at IV doses up to 15 mg iron/kg/dose [about 10 times the maximum recommended human dose for a 70 kg person] given three times a week was found to have no effect on fertility . Separate by 2 hr. The iron formulation choice remains for the clinician to make. The usual total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. Use Caution/Monitor. Recommended dosing and infusion rates for PI. Applies only to oral form of both agents. Dosage: For patients weighing 50 kg (110 lb) or more: Give Injectafer in two doses separated by at least 7 days. NOTES: Lab and/or medical tests (such as complete blood count, ferritin, transferrin, total iron binding capacity-TIBC) should be done while you are using this medication. *Repeat dose if iron deficiency anemia reoccurs. Steps on how to print your input & results: 1. DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. Use Caution/Monitor. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. iron sucrose decreases levels of minocycline by inhibition of GI absorption. Give each dose as 15 mg/kg body weight for a total cumulative dose not to exceed 1500 mg of iron per course. rabeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Modify Therapy/Monitor Closely. Nutrition. Ferumoxytol [ Feraheme ] Elemental iron: 510 mg/17 mL (17 mL) 30 mg/mL [package insert] - Boxed warning REVIEW INSERT. Adult Patients with Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD): Administer Venofer 200 mg undiluted as a slow intravenous injection over 2 to 5 minutes or as an infusion of 200 mg in a maximum of 100 mL of 0.9% NaCl x 15 minutes. Applies only to oral form of both agents. Either increases effects of the other by pharmacodynamic synergism. Observed Hb = the patients current hemoglobin in g/dl. Access your plan list on any device mobile or desktop. Then you can click on the Print button to open a PDF in a separate window with the inputs and results. 1995 Mar-Apr;11(2):163-8. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. It varies from increases in dietary intake of iron (usually for prophylaxis purposes) to oral, intramuscular or intravenous therapy. Ensure the Intravenous Iron Checklist (see trust guideline) has been completed. Ferrlecit has been administered at sequential dialysis sessions by infusion or by slow intravenous injection during the dialysis session itself. Indicated for treatment of iron deficiency anemia associated with chronic kidney disease, Hemodialysis-dependent CKD: 100 mg elemental iron IV (injection or infusion over 2-5 min) per dialysis session not to exceed total cumulative dose of 1000 mg divided in 3 doses/week, Non-dialysis-dependent CKD: 200 mg IV injection for 5 doses in over 14 days (cumulative 1000 mg in 14-day period), Peritoneal dialysis-dependent CKD: 300 mg IV infusion (1.5 hr) for 2 doses 14 days apart, THEN 400 mg IV infusion (2.5 hr) 14 days later (cumulative 1000 mg divided in 3 doses/week), Indicated for maintenance treatment of iron-deficient anemia associated with chronic kidney disease, <2 years: Safety and efficacy not established, Iron replacement treatment in pediatric patients has not been established. FOR PATIENTS WEIGHING 50 kg OR MORE: Administer 1000 mg of Monoferric by intravenous infusion 20 minutes as a single dose 1. Applies only to oral form of both agents. Administer Feraheme as an intravenous infusion in 50-200 mL 0.9% Sodium Chloride Injection, USP or 5% Dextrose Injection, USP over at least 15 minutes. Modify Therapy/Monitor Closely. Use Caution/Monitor. HONcode standard for trust- worthy health, Pediatric Oncology: Diagnosis And Prognosis Communication. David McAuley, Pharm.D. Serious - Use Alternative (1)iron sucrose decreases levels of levofloxacin by inhibition of GI absorption. deferoxamine decreases levels of iron sucrose by inhibition of GI absorption. calcium chloride decreases levels of iron sucrose by inhibition of GI absorption. A healthcare provider will give you this injection. Oral and parenteral products - see background option for oral products. omeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. sodium bicarbonate will decrease the level or effect of iron sucrose by increasing gastric pH. By entering this website, you acknowledge that you are a licensed healthcare professional practicing in the United States. The normal ranges are: for males 13.8 to 18.0 g/dL (138 to 180 g/L, or 8.56 to 11.17mmol/L) and for females 12.1 to 15.1 g/dL (121 to 151 g/L, or 7.51 to 9.37mmol/L). Applies only to oral form of both agents. iron sucrose decreases levels of deferiprone by enhancing GI absorption. Alldredge BK, Corelli RL, Ernst ME, Guglielmo BJ, eds. View the formulary and any restrictions for each plan. US residents can call their local poison control center at 1-800-222-1222. Manage and view all your plans together even plans in different states. Use Caution/Monitor. Use Caution/Monitor. Your body may also need more iron if you use the drug erythropoietin to help make new red blood cells.Iron is an important part of your red blood cells and is needed to transport oxygen in the body. Am J Kid Dis 2001; 38 988991. Iron stores are input as default 500 mg on the assumption that the patient weight is greater or equal to 35 kg (77 lbs). The weight of the patient is taken into account in order to estimate iron stores, while haemoglobin is required as both current measured and target. The dosing for iron replacement treatment in pediatric patients with HDD-CKD has not been established. Share cases and questions with Physicians on Medscape consult. Compare formulary status to other drugs in the same class. Either increases effects of the other by pharmacodynamic synergism. A patients lean body weight (or actual body weight if less than lean body weight) should be utilized when determining dosage. Minor (1)iron sucrose decreases levels of manganese by inhibition of GI absorption. Use Caution/Monitor. Separate by at least 4 hours. No additional iron to replenish stores. Separate dosing of tetracyclines from these products. Alternatively the total dose may be calculated: Dose (mL) = 0.0442 (Desired Hb - Observed Hb) x LBW + (0.26 x LBW) Based on: Desired Hb = the target Hb in g/dl. Applies only to oral form of both agents. Last updated 28/06/2018 Enter values here and press 'Calculate'. Anemia; 2015: 763576. Maximum recommended single dose: 300 mg (See Prescriber's Orders). PRECAUTIONS: Before using iron sucrose, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. Applies only to oral form of both agents. This drug is available at the lowest co-pay. Separate by 2 hr. Schweiz Med Wochenschr; 100(7):301-3. (See also Notes section. Minor/Significance Unknown. The dosing for iron replacement treatment in pediatric patients with hemodialysis-dependent chronic kidney disease (HDD-CKD), non-dialysis-dependent chronic kidney disease (NDD-CKD) or peritoneal-dialysis-dependent chronic kidney disease (PDD-CKD) has not been established. There are physiological variation in iron reserves such as the decrease during menstruation period. There are four fields that need to be completed: Weight body weight is used to establish iron deficit and is also taken into account when estimating the iron stores. Monitor Closely (1)iron sucrose will decrease the level or effect of omadacycline by inhibition of GI absorption. Sodium ferric gluconate (Ferrlecit) 62.5 mg . Avoid or Use Alternate Drug. By taking into account the case of a patient weighing 78 kg (172 lbs) and having a hemoglobin level of 11 g/dL (110 g/L or 6.83 mmol/L).

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